480.Hirschsprung's disease indicates a developmental abnormality in which of the following embryonic tissues?

 A. Ectoderm
B. Endoderm
C. Neural crest
D. Neural ectoderm

Ans-c.Neural crest

The baby has Hirschsprung's disease, which is due to an absence of
ganglion cells in the wall of the colon. Neural crest cells contribute to the formation of many adult
structures. Among these are all of the postganglionic neurons of the autonomic nervous system and
the sensory neurons of the peripheral nervous system.

479.At which of the following ages does fetal movement first occur?

A. 1 month
B. 2 months
C. 4 months
D. 6 months

Ans-B.2months
Neuromuscular development is sufficient to allow fetal movement in the
eighth week of life. Other features of Week 8 include the first appearance of a thin skin, a head as
large as the rest of the body, forward-looking eyes, appearance of digits on the hands and feet,
appearance of testes and ovaries (but not distinguishable external genitalia), and a crown-rump length
of approximately 30 mm. By the end of the eighth week, nearly all adult structures have at least begun
to develop, and the fetus "looks like a baby.

478 :Bleeding joints is a characteristic feature of:

  1. Vitamin C deficiency.
  2. Hemophilia.  
  3. Vitamin K deficiency. 
  4. Thrombocytopenia.

Ans-2.Hemophilia

477:Auspitz’s sign is seen in:

  A. Lupus erythematosus 
  B Pemphigold  
  C. Lichen planus 
  D. None of the above

   Ans-D.None of the above

476.Chemfill is

a.Compomer
b.Resin modified GIC
c.GIC
d.Composite

Ans-b.Resin modified GIC

475. Within the RBC, hypoxia stimulates glycolysis by which of the following regulatory pathwayse

a.      Hypoxia stimulates pyruvate dehydrogenase by increased 2,3-DPG

b.      Hypoxia inhibits hexokinase

c.      Hypoxia stimulates release of all glycolytic enzymes from Band -3 on RBC membrane

d.      Activation of the regulatory enzymes by high PH

474.Auditory centre for hearing lies in the

a.Precentral gyrus
b.Post central gyrus
c.Temporal lobe
d.Occipital lobe



Ans-c.Temporal lobe

Ref -BDC 4TH ED VOL III PG 351

473.Cranium development is started at the age of

a.11 days
b.21 days
c.31 days
d.41 days



Ans-b.21 days 

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472.All are true about propofol except

a.Induction and maintenance of anaesthesia
b.Induces vomitting
c.Causes sedation
d.Rapid recovery

Ans-b.Induces vomiting

471.Denaturation of double stranded DNA results in

a.It gets broken down to nucleotides.
b.It becomes single stranded reversibly.
c.Becomes single stranded iireversibly.
d.Becomes double stranded permanently.

Ans-b.It becomes single stranded reversibly.

470.All potentiate digoxin toxicity except

a.Hyperkalemia
b.Hypomagnesia
c.Hypercalcemia
d.Renal failure

Ans-a.Hyperkalemia
 Ref-Katzung pg 54-55   10th ed
Hyperkalemia is a protective factor as in the presence of hyperkalemia,the binding of digoxin becomes less

469.Substance P is released in response to pain in periphery

a.Nerve terminalis
b.Mast cells
c.Endothelium
d.Plasma

Ans-a.Nerve terminalis

Ref -Ganong's review of medical physiology 23 rd ed pg 112

468.The sulcular epethilium acts as a semipermeable membrane through which

a.Bacterial products pass into the gingiva.
b.Fluids from the gingiva seep into the sulcus.
c.Both of the above.
d.None of the above.


Ans-c. Both of the above
Ref-Caranza 9 th ed pg 23

467.Etiology of multiple neurofibromatosis is

a.Genetic
b.Viral
c.Injury
d.Endocrine


Ans-a.Genetic

Reference-Shafer's 5th ed pg 280